International PerimenopauseAlliance

What we aim to do

A raised hand with gently curved fingers, in orange and pink duotone.

  1. Make perimenopause an international priority

    for women's cardiovascular health, in research, clinical care and public health.

  2. Define the window

    with evidence-based criteria to recognize the onset and progression of the transition in each woman, early enough to act.

  3. Expand research on recognition

    including validated, accessible methods to characterize the transition beyond bleeding patterns and single hormone measurements.

  4. Expand research on mechanism

    to characterize the trajectory and variability of ovarian hormones across the transition and how they relate to lipid metabolism, endothelial function, arterial remodeling, blood pressure, and the development of atherosclerotic cardiovascular disease and stroke.

  5. Translate evidence into prevention

    through randomized studies of timely risk-factor management, lifestyle intervention and symptom relief in perimenopausal women, with cardiovascular endpoints.

  6. Build transatlantic cohorts

    with harmonized protocols, frequent hormone sampling and sex-disaggregated data.

  7. Include women in the transition in clinical trials

    where they remain underrepresented.

  8. Integrate care

    through combined cardiology and gynecology models for midlife women, in line with the call for Centers of Excellence in women's cardiovascular care.

  9. Equip clinicians

    to recognize perimenopause as a cardiovascular risk window, assess hormonal and cardiovascular health together, and act on risk enhancers such as persistent hot flashes.

  10. Partner with professional societies

    on joint statements, education and research priorities, complementing their work.

  11. Raise awareness

    among women and clinicians that midlife changes in the cycle and symptoms are a signal for the heart.